This platform enables you to verify and enhance biological networks models. The NVC3 focuses on three network models that represent biotransformation and chemical elimination involved in Phase I, Phase II, and Phase III, respectively, of the xenobiotic metabolism in the liver.
The networks will be released for commenting and editing sequentially, starting with Phase I.
- Phase I Xenobiotic Metabolism encompasses the biochemical reactions that introduce reactive and polar groups into xenobiotic compounds by oxidation, reduction, or hydrolytic reactions. One of the most common modifications is hydroxylation catalyzed by the cytochrome P-450-dependent mixed-function oxidase system. The phase I network model describes signaling that leads to the activation of P450 family enzymes. Important nuclear receptors, such as nuclear receptor subfamily 1 group I member 2 (Nr1i2), nuclear receptor subfamily 1 group I member 3 (Nr1i3), the aryl hydrocarbon receptor (Ahr), and the peroxisomal proliferator-activated receptors alpha (Ppara) mediate this signal.
- In subsequent phase II reactions, these activated xenobiotic metabolites are conjugated with charged species. The phase II Xenobiotic Metabolism Network Model describes the activation of UDP-glucuronosyltransferases, sulfotransferases, N-acetyltransferases, glutathione S-transferases and highlights the importance of nuclear factor, erythroid 2 like 2 (Nfe2l2), and nuclear receptor subfamily 3 group C member 1 (Nr3c1) in the transformation process.
- In the final step, the phase III Xenobiotic Metabolism Network Model describes the xenobiotic excretion from cells. It is mediated by the activation of molecular transporters, such as ATP-binding cassette subfamily B (Abcb), ATP-binding cassette subfamily G (Abcg), ATP-binding cassette subfamily C (Abcc), and ATP-binding cassette subfamily A (Abca).
The full text search available below can be used to search for networks, nodes, edges, and publications (by their Pubmed ID).
Search the Bionet networks for network names, nodes, edges, PubmedID's and Synonyms
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